Treatable

Polymyxin B

Polymyxin-class Antibacterial

Polymyxin B Ophthalmic Ointment

DosageBrandImage
bacitracin 0.4 UNT/MG / hydrocortisone 0.01 MG/MG / neomycin 0.0035 MG/MG / polymyxin B 10 UNT/MG Ophthalmic OintmentGeneric
bacitracin 0.4 UNT/MG / hydrocortisone 0.01 MG/MG / neomycin 0.0035 MG/MG / polymyxin B 10 UNT/MG Ophthalmic Ointment [Vetropolycin HC]Generic
bacitracin 0.4 UNT/MG / neomycin 0.0035 MG/MG / polymyxin B 10 UNT/MG Ophthalmic OintmentGeneric
bacitracin 0.4 UNT/MG / neomycin 0.0035 MG/MG / polymyxin B 10 UNT/MG Ophthalmic Ointment [Neo-Polycin]Generic
bacitracin 0.4 UNT/MG / neomycin 0.0035 MG/MG / polymyxin B 10 UNT/MG Ophthalmic Ointment [Triplicin]Generic
bacitracin 0.4 UNT/MG / neomycin 0.0035 MG/MG / polymyxin B 10 UNT/MG Ophthalmic Ointment [Vetropolycin]Generic
bacitracin 0.5 UNT/MG / polymyxin B 10 UNT/MG Ophthalmic OintmentGeneric
bacitracin 0.5 UNT/MG / polymyxin B 10 UNT/MG Ophthalmic Ointment [Polycin]Generic
bacitracin zinc 0.4 UNT/MG / hydrocortisone acetate 0.01 MG/MG / neomycin sulfate 0.0035 MG/MG / polymyxin B sulfate 10 UNT/MG Ophthalmic OintmentGeneric
bacitracin zinc 0.4 UNT/MG / hydrocortisone acetate 0.01 MG/MG / neomycin sulfate 0.0035 MG/MG / polymyxin B sulfate 10 UNT/MG Ophthalmic Ointment [Neo-Polycin HC]Generic
dexamethasone 0.001 MG/MG / neomycin 0.0035 MG/MG / polymyxin B 10 UNT/MG Ophthalmic OintmentGeneric
dexamethasone 0.001 MG/MG / neomycin 0.0035 MG/MG / polymyxin B 10 UNT/MG Ophthalmic Ointment [Maxitrol]Generic
dexamethasone 0.001 MG/MG / neomycin 0.0035 MG/MG / polymyxin B 10 UNT/MG Ophthalmic Ointment [Poly-Dex]Generic
oxytetracycline 0.005 MG/MG / polymyxin B 10 UNT/MG Ophthalmic OintmentGeneric

Polymyxin B Topical Ointment

DosageBrandImage
bacitracin 0.4 UNT/MG / hydrocortisone 0.01 MG/MG / neomycin 0.0035 MG/MG / polymyxin B 5 UNT/MG Topical OintmentGeneric
bacitracin 0.4 UNT/MG / hydrocortisone 0.01 MG/MG / neomycin 0.0035 MG/MG / polymyxin B 5 UNT/MG Topical Ointment [Cortisporin Ointment]Generic
bacitracin 0.4 UNT/MG / neomycin 0.0035 MG/MG / polymyxin B 10 UNT/MG / pramoxine hydrochloride 0.01 MG/MG Topical OintmentGeneric
bacitracin 0.4 UNT/MG / neomycin 0.0035 MG/MG / polymyxin B 10 UNT/MG / pramoxine hydrochloride 0.01 MG/MG Topical Ointment [Lanabiotic]Generic
bacitracin 0.4 UNT/MG / neomycin 0.0035 MG/MG / polymyxin B 10 UNT/MG / pramoxine hydrochloride 0.01 MG/MG Topical Ointment [Mycitracin Plus Pain Reliever]Generic
bacitracin 0.4 UNT/MG / neomycin 0.0035 MG/MG / polymyxin B 10 UNT/MG / pramoxine hydrochloride 0.01 MG/MG Topical Ointment [Spectrocin Plus]Generic
bacitracin 0.4 UNT/MG / neomycin 0.0035 MG/MG / polymyxin B 5 UNT/MG Topical OintmentGeneric
bacitracin 0.5 UNT/MG / neomycin 0.0035 MG/MG / polymyxin B 10 UNT/MG / pramoxine hydrochloride 0.01 MG/MG Topical OintmentGeneric
bacitracin 0.5 UNT/MG / neomycin 0.0035 MG/MG / polymyxin B 10 UNT/MG / pramoxine hydrochloride 0.01 MG/MG Topical Ointment [Cuadriderma]Generic
bacitracin 0.5 UNT/MG / neomycin 0.0035 MG/MG / polymyxin B 10 UNT/MG / pramoxine hydrochloride 0.01 MG/MG Topical Ointment [Tri Biozene]Generic
bacitracin 0.5 UNT/MG / neomycin 0.0035 MG/MG / polymyxin B 10 UNT/MG Topical OintmentGeneric
bacitracin 0.5 UNT/MG / neomycin 0.0035 MG/MG / polymyxin B 5 UNT/MG / pramoxine hydrochloride 0.01 MG/MG Topical OintmentGeneric
bacitracin 0.5 UNT/MG / polymyxin B 10 UNT/MG Topical OintmentGeneric
bacitracin 0.5 UNT/MG / polymyxin B 10 UNT/MG Topical Ointment [Polysporin]Generic

Polymyxin B Irrigation Solution

Polymyxin B Injectable Solution

What is Polymyxin B Sulfate?

Polymyxin b sulfate (also called polymyxin b, or polymyxin) is an antibiotic used to treat Gram-negative infections such as meningitis and sepsis. It can be administered via the inhalation route or via injection.

What is Polymyxin B Used For?

  • Meningitis
  • Sepsis
  • Urinary Tract Infection
  • Pneumonia
  • Skin and blood infections
  • Conjunctivitis
  • Styes

Polymyxin is used to treat infections caused by Gram-negative bacteria. Gram-negative bacteria have a thin cell wall made of a substance called peptidoglycan. The bacteria got its name from the Gram test, where it is easily stained with lab dye.

Because of the thin cell wall, Gram-negative bacteria can be killed using polymyxin, whereas Gram-positive bacterial infections cannot.

How does polymyxin work?

Polymyxin works by killing the bacteria causing the infection. By destroying the membrane of the Gram-negative cells (with the weak cell wall), polymyxin prevents the cell from carrying the infection around the body.

Once the cells are destroyed, polymyxin disinfects the body and removes any remaining infection from the area.

Types of Polymyxin b

Polymyxin can be administered via the respiratory system, the veins or the spinal fluid. The inhalation (respiration) route uses an aerosol or dry inhaler that the patient breathes. Intravenous (veins) or intrathecal (spinal) administration must be conducted by a medical practitioner.

Polymyxin b dosing protocol

When administered intravenously, the recommended adult dose for polymyxin b is 15,000-25,000 units daily per kg of body weight, split into two doses. If injected into the muscle, the units are slightly higher at 25,000-30,000 split over four doses.

When injected into the spinal fluid, 50,000 units for adults should be given for the first 3-4 days and then every other day or daily.

The maximum dose for adults is 2million units, regardless of body weight.

Children may have the same dose as adults (per kg of body weight) but intravenous and intramuscular administration should always be split into two doses a day (every 12 hours).

For patients of all ages with kidney failure, doses should be between 15% and 75-100% of the standard adult doses.

Eye drops should be administered to the infected eye, 1 drop per eye every 3 hours, up to 6 times a day.

Polymyxin Side Effects

Polymyxin is safe to use, but it can cause some side effects, including:

  • Blurry vision or stinging from eye drops
  • Fever
  • Flushing
  • Tingling hands
  • Numbness
  • Hives
  • Stiff back or neck
  • Poor balance
  • Dizziness
  • Drowsiness
  • Headaches

The most common side effect of polymyxin b is pain at the site of injection, and this is most likely to occur if administered into the muscle. If eye drops are used, blurred vision and stinging or itchiness may occur, but all these side effects are usually temporary.

More serious side effects, such as a fever, tingling or numb limbs, loss of balance, dizziness and a rash, should be examined by a doctor. If side effects persist, also seek medical attention.

FAQs

Can I use polymyxin b sulfate for pink eye?

Yes. Polymyxin eye drops are a great way to treat conjunctivitis (pink eye). They work by killing the bacteria and safely disinfecting the eye.

How to use neomycin and polymyxin b sulfates for eyes?

Drop one drop into the affected eye, up to 6 times a day as needed. Do not touch your eye with the dropper and do not exceed 6 drops a day (per eye if both are infected).

What is polymyxin b eye drops used for?

Polymyxin b eye drops are used for treating eye infections such as conjunctivitis and styes.

What is polymyxin b trimethoprim?

Polymyxin b and trimethoprim are often used together to treat conjunctivitis. You can find eye drops containing both medicines but check with the pharmacist if you are not sure which eye drops are best for you.

What is neomycin and polymyxin b used for?

Neomycin and polymyxin b are often used together to treat external ear infections. Usually, these two antibiotics will also be mixed with an anti-inflammatory, to help reduce swelling.

Does polymyxin b sulfate have sulfa in it?

Yes. Polymyxin b contains sulfa, however it is safe for anyone with a sulfa allergy to use sulfa-based eye drops.

Is polymyxin b sulfate used for styes?

Yes. Polymyxin is commonly used to reduce the severity and occurrence of styes.

Some conditions that polymyxin might help

Conjunctivitis

Studies show a combination of trimethoprim and polymyxin to be an effective treatment for acute conjunctivitis in 95% of cases.

Meningitis

Polymyxin is an effective treatment for Gram-negative meningitis when administered both intravenously and intrathecally.

Multiple studies have supported the use of polymyxin. Daily doses ranged from 20,000 to 250,000 micrograms for adults and 5,000 to 120,000 micrograms for children. These studies found that polymyxin is not just effective but also safe for use.

Sepsis

Sepsis – and resulting septic shock – is a potentially fatal complication from infections of any severity. Polymyxin has been found to effectively improve heart and kidney function in patients with sepsis, but more research is needed to support its use clinically.

Pneumonia

Studies have found that 500,000 micrograms of polymyxin inhaled twice daily can effectively improve if not heal pneumonia symptoms in patients that are otherwise unresponsive to medication.

Urinary Tract Infection

A review of studies on the effectiveness of polymyxin on gram-negative conditions found it to be an effective treatment for UTIs. These studies examined multiple administration methods and found that 150-250mg was most the common dosage.

Polymyxin B contraindicated conditions:

Polymyxin B desired effects:

  • Cellular Structure Alteration

Polymyxin B drug classes:

  • Polymyxin-class Antibacterial

Polymyxin B pharmacologic actions:

  • Anti-Bacterial Agents
  • Anti-Infective Agents, Local

Polymyxin B mechanism of action:

  • Acid-Base Activity
  • treatable

The content offered on Treatable.org is intended for informational purposes only and not as medical advice. For medical advice you should consult an appropriately licensed and qualified medical professional. If you are experiencing acute or distressing symptoms or life threatening symptoms you should immediately call 911 and/or go to the nearest emergency medical facility.

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Last updated: 1/23/2022, 3:30:09 PM