Lumacaftor is a medication used to treat cystic fibrosis sold under the brand name Orkambi. Lumacaftor improves the underlying disease in cystic fibrosis bringing more mature CFTR proteins to the cell surface.

Lumacaftor may treat:

Lumacaftor mechanism of action:

  • Cytochrome P450 3A Inducers
  • Cytochrome P450 2B6 Inducers
  • P-Glycoprotein Inducers
  • Cytochrome P450 2C8 Inducers
  • P-Glycoprotein Inhibitors
  • Cytochrome P450 2C19 Inducers
  • Chloride Channel Activation Potentiators
  • Cytochrome P450 2C8 Inhibitors
  • Cytochrome P450 2C9 Inhibitors
  • Cytochrome P450 2C9 Inducers
  • treatable

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Last updated: 10/19/2022, 6:44:33 AM