Treatable

Dactinomycin

Actinomycin

Brands

Dactinomycin injection

DosageBrandImage
dactinomycin 0.5 MG Generic
dactinomycin 0.5 MG Cosmegen

Dactinomycin side effects

Adverse Event ReportedReporting Odds RatioCase Count
Nephroblastoma2251.7504318
Maternal exposure before pregnancy555.1699781
Ototoxicity398.0594740
Treatment related secondary malignancy232.7558417
Venoocclusive disease176.1809140
Venoocclusive liver disease150.2914364
Myelitis transverse105.04513
Myelitis88.00589
Febrile bone marrow aplasia71.773127
Recurrent cancer65.1046210
Renal cell carcinoma stage unspecified56.73989
Growth retardation56.4253310
Thyroid cancer50.9801719
Neoplasm recurrence42.626679
Bone marrow depression39.592312
Neutropenic sepsis34.1092330
Renal tubular disorder21.387269
Tumour lysis syndrome21.0723914
Febrile neutropenia19.15008126
Disease recurrence18.6837129
Mucosal inflammation17.9414149
Endocarditis16.712499
Hepatomegaly15.2352822
Haematotoxicity15.180318
Metastases to lymph nodes14.803788
Drug resistance14.7884310
Acute myeloid leukaemia13.3734618
Blood culture positive12.7463410
Ascites12.1334739
Metastases to lung12.0616511

Dactinomycin desired effects:

  • Decreased DNA Integrity
  • Decreased Protein Synthesis
  • Decreased RNA Integrity

Dactinomycin contraindicated conditions:

Dactinomycin drug classes:

  • Actinomycin

Dactinomycin pharmacologic actions:

  • Antibiotics, Antineoplastic
  • Protein Synthesis Inhibitors
  • Nucleic Acid Synthesis Inhibitors
  • Anti-Bacterial Agents

Dactinomycin mechanism of action:

  • Nucleic Acid Synthesis Inhibitors
  • Protein Synthesis Inhibitors
  • treatable

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Last updated: 7/16/2021, 8:05:41 AM