Lincosamide Antibacterial

Clindamycin Topical Foam

Clindamycin Topical Solution

Clindamycin Vaginal Insert

What is clindamycin

Clindamycin is a lincomycin antibiotic used to treat serious (Gram-positive) bacterial infections. It is often used where other antibiotics are not appropriate and is in the same category of antibiotics as penicillin. Clindamycin is commonly used to treat skin, blood, reproductive and respiratory infections.

What is clindamycin used for?

  • Endocarditis
  • Blood, skin and bone infections
  • Septicemia
  • Internal organ infections
  • Reproductive infections

Clindamycin treats bacterial infection throughout the body and is often used in place of penicillin where the patient is allergic.

How does clindamycin work?

Clindamycin is an antibiotic, so it works by preventing bacteria from creating the proteins it needs to grow. This stops the bacteria from reproducing, which eventually kills off the infection.

Clindamycin dosage

Clindamycin can be administered orally, intravenously or topically as foam or an ointment.

The recommended dosage depends on the severity of the infection, but ranges as follows for adults:

  • Oral clindamycin: between 150mg and 600mg administered every 6 hours
  • Intravenous clindamycin: between 600mg and 4800mg daily split between 2-4 doses.
  • Topical clindamycin: a thin layer of foam or ointment once daily.

A doctor will prescribe a lower dose for children, according to their body weight and starting at 37.5mg 3 times a day (oral) and 15mg per kg of body weight per day split over 3-4 doses (intravenous).

Clindamycin Side Effects

Clindamycin is safe to use but has some serious and common side effects. For that reason, it is only usually prescribed where other antibiotics cannot be used. It can cause irritation and other problems along the digestive system, including severe diarrhea, nausea and cramps.

As well as stomach complaints, possible side effects are skin sensitivity, peeling and rash as well as blisters and swelling around your face and mouth. If you experience any of these side effects, stop taking the medicine and speak to your doctor about how to proceed.


Can you take antacids with clindamycin?

You generally should not take antacids with any antibiotic because they can delay the uptake of the drug. If you need to take both, leave a 2-hour gap between the medications.

Can you overdose on clindamycin?

Yes. Taking too much clindamycin is very dangerous. Not only does it increase the chance of severe side effects, but it can also cause convulsions, low blood pressure and paralysis.

Is clindamycin a powerful antibiotic?

Yes. Clindamycin is a powerful antibiotic. It is generally only used when others (such as penicillin) are not suitable, as it has some severe side effects.

Is clindamycin safe in pregnancy?

Yes. Clindamycin is prescribed to pregnant women with vaginal infections because it has been found safe and effective.

Does clindamycin make you tired?

Tiredness and fatigue are side effects of clindamycin, and most antibiotics, but if this becomes excessive then speak to your doctor.

Can I take ibuprofen with clindamycin?

You can probably take ibuprofen with clindamycin but ask your prescribing doctor first.

Does clindamycin affect birth control?

Clindamycin might make some birth control (Ethinyl estradiol) less effective, so make sure you let your doctor know any other medications you are taking.

Does clindamycin cover MRSA?

Yes. Clindamycin has been found to effectively treat infection in children with Methicillin-resistant Staphylococcus aureus (MRSA).

Why can't you lay down after taking clindamycin?

Laying down immediately after taking clindamycin can cause esophageal inflammation and heartburn.

Can I use moisturizer after clindamycin?

You can apply moisturizer at least 1 hour from applying clindamycin.

Can clindamycin cause yeast infection?

Yes. All antibiotics can cause a yeast infection.

Can you drink alcohol with clindamycin?

Yes. There are no interactions between clindamycin and alcohol, so you can drink while taking the antibiotic.

Is clindamycin a macrolide?

Yes. Clindamycin is a macrolide antibiotic.

Is clindamycin a penicillin?

No. Clindamycin is not penicillin, it is a lincomycin antibiotic, but it is used when penicillin is not a safe option.

How long does it take for clindamycin to work?

Clindamycin takes a couple of days to work. Make sure you complete your course even after your symptoms disappear.

How long do clindamycin side effects last?

Side effects of clindamycin can last up to 2 months after stopping your treatment. Seek medical care if your side effects seem severe or last longer than this.

What kind of infections does clindamycin treat?

Clindamycin treats bacterial infections.

Conditions clindamycin might help


Studies show that taking clindamycin for acne leads to significantly fewer pustules and papules, as well as an improved perception of acne severity. 1% clindamycin phosphate was applied topically twice daily for 8 weeks, with results appearing after 2 weeks.

Bacterial Vaginosis

2% intravaginal clindamycin cream and oral clindamycin have been found to cure bacterial vaginosis in 80-90% and over 90% of cases, respectively. It also prolonged


Research supports the use of clindamycin for endocarditis. One study found that personalised doses of oral and intravenous clindamycin reduced time in hospital and severity of endocarditis as effectively as intravenous clindamycin, but with less severe side effects.


One study found 20-30mg per kg of bodyweight of clindamycin administered daily over 3 doses to effectively treat osteomyelitis and septic arthritis in children.


Studies have found that taking clindamycin for tooth infection is effective in reducing bleeding, plaque and probing depth. 300mg of clindamycin was taken 3 times a day by diabetic patients for a total of 7 days.

Preoperative prophylaxis

Multiple studies have found that clindamycin can prevent infection during preventative surgeries for a variety of cancers.


Research shows that clindamycin is more effective than penicillin and erythromycin in eradicating GABHS colonization in patients with recurring tonsillitis.

Clindamycin may prevent:

Clindamycin desired effects:

  • Decreased Protein Synthesis
  • Decreased Sebaceous Gland Activity

Clindamycin drug classes:

  • Lincosamide Antibacterial

Clindamycin pharmacologic actions:

  • Anti-Bacterial Agents
  • Dermatologic Agents
  • Protein Synthesis Inhibitors

Clindamycin mechanism of action:

  • Protein Synthesis Inhibitors
  • treatable

The content offered on is intended for informational purposes only and not as medical advice. For medical advice you should consult an appropriately licensed and qualified medical professional. If you are experiencing acute or distressing symptoms or life threatening symptoms you should immediately call 911 and/or go to the nearest emergency medical facility.

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Last updated: 1/27/2022, 11:53:41 AM